- Chemical Name: 3,5-BIS(TRIFLUOROMETHYL)BENZHYDRAZIDE
- CAS No.: 26107-82-4
High Quality Chinese Manufacturer supply 26107-82-4 3,5-BIS(TRIFLUOROMETHYL)BENZHYDRAZIDE
- Molecular Formula: C9H6F6N2O
- Molecular Weight: 272.15
- Appearance/Colour: white crystalline powder
- Melting Point: 131-135 °C
- Refractive Index: 1.442
- PKA: 11.21±0.10(Predicted)
- PSA： 55.12000
- Density: 1.479 g/cm3
- LogP: 3.41890
3,5-BIS(TRIFLUOROMETHYL)BENZHYDRAZIDE(Cas 26107-82-4) Usage
InChI:InChI=1/C9H6F6N2O/c10-8(11,12)5-1-4(7(18)17-16)2-6(3-5)9(13,14)15/h1-3H,16H2,(H,17,18)
26107-82-4 Relevant articles
AMINO ALCOHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
-
, (2021/11/13)
The present invention belongs to the fie...
Synthesis, fungicidal activity, and 3D-QSAR of tetrazole derivatives containing phenyloxadiazole moieties
Li, Yi-Tao,Yao, Wen-Qiang,Zhou, Si,Xu, Jun-Xing,Lu, Hui,Lin, Jian,Hu, Xiao-Yun,Zhang, Shao-Kai
supporting information, (2021/01/11)
In an effort to discover new agents with...
Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles
Bai, Hangyu,Jiang, Weiqi,Li, Qi,Li, Tian,Ma, Shichuang,Shi, Baojun,Wu, Wenjun
, p. 11572 - 11581 (2021/10/12)
A series of novel steroidal derivatives ...
Antinociceptive and cytotoxic activity of opioid peptides with hydrazone and hydrazide moieties at the C-terminus
Bochynska-Czyz, Marta,Dyniewicz, Jolanta,Kosson, Piotr,Lipinski, Piotr F. J.,Matalinska, Joanna,Misicka, Aleksandra
, (2020/09/16)
In the present contribution, we analyze ...
26107-82-4 Process route
-
-
725-89-3
3,5-bistrifluoromethylbenzoic acid
-
-
26107-82-4
3,5-bis-(trifluoromethyl)benzoic acid hydrazide
| Conditions | Yield |
|---|---|
|
3,5-bistrifluoromethylbenzoic acid;
With
4-methyl-morpholine; isobutyl chloroformate;
In
tetrahydrofuran;
at 20 ℃;
for 1.5h;
With
hydrazine;
In
tetrahydrofuran;
for 5h;
|
|
|
|
|
|
3,5-bistrifluoromethylbenzoic acid;
With
1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 2.5h;
With
hydrazine hydrate;
In
N,N-dimethyl-formamide;
for 20h;
|
|
|
Multi-step reaction
with
2
steps
1.1: thionyl chloride / 1 h / Cooling with ice
1.2: 1 h / 80 °C
2.1: hydrazine hydrate / methanol / 20 °C / Inert atmosphere
With
thionyl chloride; hydrazine hydrate;
In
methanol;
|
-
-
26107-80-2
3’,5’-bis(trifluoromethyl)acetophenone
-
-
26107-82-4
3,5-bis-(trifluoromethyl)benzoic acid hydrazide
| Conditions | Yield |
|---|---|
|
With
hydrazine hydrate;
In
methanol;
at 40 ℃;
for 16h;
Inert atmosphere;
|
81.6%
|
|
With
hydrazine hydrate;
In
methanol;
at 10 - 80 ℃;
for 6h;
|
|
|
With
hydrazine hydrate;
In
methanol;
at 20 ℃;
Inert atmosphere;
|
1.5 g
|
26107-82-4 Upstream products
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725-89-3
3,5-bistrifluoromethylbenzoic acid
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785-56-8
3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride
-
26107-80-2
3’,5’-bis(trifluoromethyl)acetophenone
-
96617-71-9
3,5-bis-trifluoromethylbenzoic acid ethyl ester
26107-82-4 Downstream products
-
220381-26-0
5-(3,5-bis(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one
-
202822-69-3
3-[(2-Methoxy-5-chlorophenyl)methyl]-5-[3,5-bis(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
-
398148-04-4
3,5-bis-trifluoromethyl-benzoic acid N -methyl-N '-naphthalen-2-ylmethyl-hydrazide